Over the past 4 years we have developed unique neonatal MRI capabilities that provide high-resolution, detailed images of lung parenchymal and vascular structures, regional cardiopulmonary function, and dynamic airway collapse, all during quiet breathing and without sedation or ionizing radiation. This collective information allows phenotyping of respiratory disease related to premature birth (bronchopulmonary dysplasia, BPD) and has the potential to significantly change the understanding and timecourse of this disease. Particularly, this provides avenues for personalized treatments via a combination of existing and new therapies.
We have established a new BPD Center that combines basic imaging research with translational medicine. The Center has four arms that focus on rigorous clinical validation of cardiopulmonary and airway MRI phenotyping (diagnostics), integration of bronchoalveolar lavage samples with a map of the developing lung, animal models, and novel drug interventions (discovery), creation of individualized treatment strategies and tailored interventions (translation), and the establishment of a clinical BPD Center of Excellence (clinical).
Personnel
BPD Center Directors |
Neonatology |
Pulmonary Medicine |
Radiology |
Cardiology |
Pulmonary Biology |
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Jason Woods, PhD |
Beth Haberman, MD |
Raouf Amin, MD |
Alan Brody, MD |
Russell Hirsch, MD |
Anne Karina Perl, PhD |
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Paul Kingma, MD PhD |
Amy Nathan, MD |
Nara Higano, PhD |
Robert Fleck, MD |
Ryan Moore, MD |
Jeff Whitsett, MD |
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Erik Hysinger, MD |
Melissa House, MD |
Alister Bates, PhD |
Andrew Schapiro, MD |
Paul Critser, MD PhD |
Marion Waltamath, PhD |
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Shawn Ahlfeld, MD |
Laura Walkup, PhD |
Mark DiFrancesco, PhD |
Burns Blaxall, PhD |
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Jennifer Brady, MD |
Erin Watters, BA |
Chamindu Gunatilaka, BS |
Melissa Magness, APRN |
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Danielle Parham, MD |
Julie Niles, RN |
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Michelle Cash, APRN |
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Nancy Roberto, APRN |
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Kelly Wendel, APRN |
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Debra Perkins, APRN |
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Whitney Cooley, RT |
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Theresia Tuttle, RT |
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References
- Bates AJ, Higano NS, Hysinger EB, Fleck RJ, Hahn AD, Fain SB, Kingma PS, Woods JC. Quantitative assessment of regional dynamic airway collapse in neonates via retrospectively respiratory-gated 1H ultrashort echo-time (UTE) MRI. J Magn Reson Imaging [accepted 2018 July].
- Higano NS, Spielberg DR, Fleck RJ, Schapiro AH, Walkup LL, Hahn AD, Tkach JA, Kingma PS, Merhar SL, Fain SB, Woods JC. Neonatal pulmonary MRI of bronchopulmonary dysplasia predicts short-term clinical outcomes. Am J Respir Crit Care Med. 2018 May 23. doi: 10.1164/rccm.201711-2287OC. [Epub ahead of print]
- Higano NS, Walkup LL, Spielberg DS, Hahn AD, Thomen RP, Merhar SL, Kingma PS, Tkach JA, Fain SB, Woods JC. Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT. J Magn Reson Imaging. 2017 Oct;46(4):992-1000. doi: 10.1002/jmri.25643.
- Hysinger EB, Friedman NL, Padula MA, Shinohara RT, Zhang H, Panitch HB, Kawut SM; Children's Hospitals Neonatal Consortium. Tracheobronchomalacia Is Associated with Increased Morbidity in Bronchopulmonary Dysplasia. Ann Am Thorac Soc. 2017 Jun 16. doi: 10.1513/AnnalsATS.201702-178OC. [Epub ahead of print]
- Higano NS, Fleck RJ, Spielberg DR, Walkup LL, Hahn AD, Tkach AJ, Merhar SL, Kingma PS, Fain SB, Woods JC. MRI-based scoring of bronchopulmonary dysplasia (BPD) correlates with disease severity and short-term outcomes. American Thoracic Society. May 19-24, 2017.
- Hysinger EB, Zhang H, Piccione J. Flexible Bronchoscopy Is Safe and Changes Management in Neonates with Severe Bronchopulmonary Dysplasia in the NICU. American Thoracic Society. May 19-24, 2017.
- Hahn AD, Higano NS, Walkup LL, Thomen RP, Cao X, Merhar SL, Tkach JA, Woods JC, Fain SB. Pulmonary MRI of neonates in the intensive care unit using 3D UTE and a small foot-print MRI system. J Magn Reson Imaging 2017, 45(2):463-471.
- Higano NS, Hahn AD, Tkach JA, Cao X, Walkup LL, Thomen RP, Merhar SL, Kingma PS, Fain SB, Woods JC. Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magn Reson Med. 2017 Mar;77(3):1284-1295. doi: 10.1002/mrm.26212.
- Walkup LL, Woods JC. Newer Imaging Techniques for Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec;42(4):871-87. doi: 10.1016/j.clp.2015.08.012.
- Walkup LL, Tkach JA, Higano NS, Thomen RP, Fain SB, Merhar SL, Fleck RJ, Amin RS, Woods JC. Quantitative magnetic resonance imaging of bronchopulmonary dysplasia in the NICU environment. Am J Respir Crit Care Med. 2015 Nov 15;192(10):1215-22. doi: 10.1164/rccm.201503-0552OC.